DOI: Debra Rose Wilson, Ph.D., MSN, R.N., IBCLC, AHN-BC, CHT, 50 to 450 milligrams of pine bark extract daily, Supplements During Pregnancy: Whats Safe and Whats Not, The ADHD Diet: What Works and What Does Not, Berberine A Powerful Supplement With Many Benefits, The Top Health Benefits of Prunes and Prune Juice, What to Know About Andrographis Supplements: Potential Benefits and Uses, Kerry Boyle D.Ac., M.S., L.Ac., Dipl. For example, Enzogenol is an extract from a pine that grows in California and Mexico (Pinus radiata) that may have cognitive-enhancing effects. A study was conducted by the Guang An Men Hospital of Chinese Medical Science Research Institutewith 77 diabetes type II patients to determine if theextract of the French Maritime pine bark provided anti-diabetic effects. after four weeks of treatment, Pycnogenol-treated patients showed definite evidence of improved in small blood vessel functions and circulation as compared to those not treated. If youre native to Oregon, you likely know all about marionberries. Pycnogenol also potentially improved cognitive function in 78 people with mild cognitive impairment. Lowers Blood Pressure. We take a look at what the science actually says. Researchers suggest that it may have stronger benefits than elastic compression stockings. Video: Why You Need Zinc and Where to Find It. In one clinical trial of 156 osteoarthritis patients, pycnogenol reduced pain, stiffness, swelling, and improved joint function after 3 months. 3. It may cause side effects such as: Risks. A study of 30 women found that Pycnogenol (75 mg/day) may reduce the skin area affected by melasma as well as lower symptoms of fatigue, constipation, body pain, and anxiety [62]. - Apply a hot compress to the anus or soaking it in a shallow tub of hot water several times a day. Researchers suggest that it may epigenetically turn off genes responsible for joint damage (ADAMTS) as well as reduce inflammation enzymes (MMP3) and cytokines (IL 1-beta) [47, 48]. Pycnogenol (150 mg/day) reduced pain in a study of 100 people with osteoarthritis after 3 months. In a good-quality study, 100 patients with osteoarthritis of the knee were treated for three months either with 150 mg of Pycnogenol a day or placebo. For most people, pine bark extract doesnt cause any side effects. It comes from the bark of a European pine tree. The supplement significantly reduced hot flashes, night sweats, mood swings, irregular periods, loss of libido, and vaginal dryness. However, its unclear how clinically effective Pycnogenol is for most of these conditions due to the low quality of evidence. Learn more about how to get even skin tone. Pycnogenol is the registered trademark name for a French formula. (7). Pine bark extract can be found in liquid, tablet or capsule form containing 85 percent to 90 percent OPCs. , Allergy: "Leukotriene E4 plasma levels in adult asthmatic patients with variable disease severity. The results of a 2013 animal study suggest that pine bark extract may help to reduce damage to nerve cells following a traumatic brain injury. This study adds to a body of research showing the benefits of Pycnogenol . According to researchers, it may help prevent the rise in free radicals typically seen after exercise, which could cause muscle fatigue and damage [9]. In the placebo group, the retinopathy worsened; whereas, in the Pycnogenol-treated group, there was no deterioration. The results showed that the combination of local and systemic applications of Pycnogenol were the best in terms of ulcer healing even though local application of Pycnogenol also speeded up ulcer healing. Herbal supplements are not regulated by the Food and Drug Administration (FDA), so they may not be up to the same safety standards as medications that have gone through clinical testing and drug trials. In combination with Mirtoselect, Pycnogenol may improve blood flow to the eye and reduce eye blood pressure as shown in a trial of 38 people [81]. Arginine is a non-essential amino acid because most humans can make it in their bodies. Erectile dysfunction has increased over the past decade or two, creating a pathway for various medications to land on the shelves of numerous medicine cabinets. Pycnogenol is the leading ingredient in Isotonix OPC-3, Market America's best-. (2017). Pycnogenol alleviated adverse effects in cancer patients, Pycnogenol improved working memory in older adults, Pycnogenol lowered the use of analgesic drugs in dysmenorrhea (severe menstrual pain), Pycnogenol reduced symptoms in endometriosis comparable to leuprorelin, the standard drug for this condition, Pycnogenol was found to be effective for sun-caused hyperpigmented skin, Pycnogenol reduced the inflammation in lupus patients, Pycnogenol reduced gingival bleeding and plaque formation. Add to Cart. (2012). It decreased concussion symptoms in 42 student-athletes with a history of sports-related concussions after 6 weeks. Pycnogenol lotions applied postirradiation reduced this immunosuppression to 22% (0.05% Pycnogenol) and 13% (0.1% Pycnogenol). (2017). Researchers suggest this benefit may be due to an increase in glutathione and SOD, two antioxidants that may reduce inflammation and oxidative stress in Crohns [76]. It also may increase the activity of genes that make collagen and hyaluronic acid in the body [64]. There is currently insufficient evidence to determine what a safe and effective dose of lysine is for specific conditions. Some small studies suggest it may also protect against coronary artery disease and blood clots. It also appeared to improve their attention span, visual motor skills, and concentration. Headaches. Enzogenol, a slightly different pine bark extract, improved cognitive function in a clinical trial of 42 older men after 5 weeks of supplementation [23]. Pine bark extract offers some amazing benefits since its so high in powerful antioxidants. Pine bark extract is usually taken by mouth in capsule form. Higher doses (200 mg/day) may improve blood vessel health and function after 8 weeks according to a study of 23 people with heart disease [38]. Thirty patients with diabetic ulcers were treated with 150 mg Pycnogenol daily for four weeks and another group of 30 comparable patients received no treatment. You can learn more about how we ensure our content is accurate and current by reading our. Once youre sure that you dont have any negative reactions, you may be able to increase your dosage according to the label. 3. Another one of its exemplary effects is helping manage blood pressure levels. A popular variety is the pinus maritime or the maritime pine that grows exclusively along the coast of southwest France. A trial of 53 students found that pycnogenol may improve cognitive function, memory, attention, mood, and mental performance after 8 weeks [20]. Ask your doctor for advice. These benefits appeared to persist for some time even after stopping supplementation [72]. Debra Rose Wilson, PhD, MSN, RN, IBCLC, AHN-BC, CHT. However, healthy people are not immune and can also develop mild infections, in particular after being in improperly chlorinated hot tubs or swimming pools. (13). Possess Anti-Inflammatory Action. They were given Pycnogenolfor a period of 10 days. Regulations set manufacturing standards for supplements, but that does not guarantee that they are safe or effective. One study suggests that Pycnogenol has no effect when given just 3 weeks beforehand, as it possibly requires a lag time to stabilize the immune response [17]. The first studied group included 66 healthy subjects in whom the number of muscle cramps was recorded two weeks before entering the study and during the fourth and fifth week. It may cause side effects such as: Dizziness. According to a study of 170 women, low-dose pycnogenol (60 mg/day) may improve menopausal symptoms over 3 months, including night sweats, hot flashes, insomnia and sleep problems [69]. It can then lead to heart problems like stroke or heart attack. You should also avoid using pine bark extract without talking to your doctor first if you: You should also do additional research or talk to your doctor before taking pine bark extract if you also take: While pine bark extract is a natural supplement, it can have powerful effects on your health, both positive and negative. Pycnogenol-treated patients reported significant improvement with knee pain, as compared to the placebo group. The staff there can often answer any questions you have and give you more information about specific brands. Pycnogenol-treated patients had significant improvement in symptoms as well as a reduction in leg swelling as compared to those not receiving treatment. For asthma in children: 1 milligram per pound of body weight given in two divided doses. Here are the many health benefits believed to be possible with Pycnogenol: Now lets dive into the first condition it could help treat. Add to Cart. While pine bark extract is thought to be safe for children, they should only take it for a few weeks at a time. However, it is also important to see beyond the pyncogenol marketing campaign and understand the possible dangers associated with this natural supplement. Theres evidence that Pycnogenol may be a promising nootropic for various groups of people, including middle-aged professionals, students, and people with mild cognitive decline like brain fog. Disease of the retina in the eye. We avoid using tertiary references. Researchers suggest this effect may be due to reduced dopamine and adrenaline levels and increased glutathione levels. 11 Skin elasticity increased, and skin fatigue decreased significantly in this study as well, further lowering the wrinkling risk. This study adds to a body of research showing the benefits of Pycnogenol for improving circulation and blood flow, strengthening the vascular system and managing cholesterol. In another trial, 30 people with type 2 diabetes received a range of pycnogenol doses. The researchers concluded that pine bark extract may increase production of hyaluronic acid and collagen, which are both found in many popular antiaging products. Almost 400 years later, Dr. Jacques Masquelier from France came across Cartiers account and started to look for the active ingredients from the bark of the tree. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Our goal is to not have a single piece of inaccurate information on this website. Your email address will not be published. 7. Can you get pycnogenol naturally from foods? Various studies, referenced at uofmhealth.org, have shown that a daily dosage of Pycnogenol . The information in our articles is NOT intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. A trial of 132 people found that Pycnogenol (150 mg/day) may improve risk factors of metabolic syndrome including lowering triglyceride levels, blood pressure, and fasting glucose, decreasing waist circumference, and increasing HDL cholesterol levels [29]. Reduces Pain. Taking pine bark extract supports healthy blood pressure. Although these may still be high quality, the active compounds are more likely to vary. In long-haul flights, Pycnogenol could be an effective prevention for blood clots. In this article, well summarize all the potential benefits and the scientific research surrounding pine bark extract and Pycnogenol. Blood clots form as a result of platelet aggregation, which is the platelets in the blood clumping together. After taking a break for one to two weeks, they can start taking it again for several weeks. Most have similar amounts of active substances and are often sold under the brand name Pycnogenol [6]. Symptoms include swelling in ankles and legs, discolored skin and, if the skin is broken, the development of leg ulcers. According to a study of 11 patients with lupus, pycnogenol may reduce symptoms, inflammation, and oxidative stress [54]. The 2012 study on the anti-aging benefits of Pycnogenol is commonly-cited by anti-aging supplement manufacturers. In a double-blind, placebo-controlled, randomized, crossover study, 50 patients with erectile dysfunction (ED) were treated with either L-arginine plus Pycnogenol or placebo for a month. Some people who have asthma have higher levels of leukotrienes in their blood. Pycnogenol is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins . Work with your pediatrician to see if there are contraindications for each child. There is limited evidence that it could be used in treating Attention Deficit Hyperactivity Disorder (ADHD). In a smaller study of 58 people, pycnogenol reduced the inflammatory marker CRP [49, 50]. - Please read carefully and implement principles included in the Health Recovery Plan. Various brands of pycnogenol are available. In a study of 77 people with symptoms of Irritable Bowel Syndrome (IBS), Pycnogenol (150 mg/day) improved symptoms and reduced the frequency of attacks [77]. Pycnogenol (100 mg/day) improved menopausal symptoms and quality of life in a clinical trial of 35 women after 8 weeks [68]. Treatment of ADHD with French maritime pine bark extract, Pycnogenol [Abstract]. The standard dose appears to be 100-200 mg/day. In a study of 50 overweight people, a combination product (Pycnogenol, Madeglucyl, and starches called Glucaffect) reduced weight, BMI, blood glucose, and HbA1C after 8 weeks [30]. Pine bark extract comes from the inner bark of the Pinus pinaster tree, most commonly found in Europe. These wounds occur most frequently in hospitals or in those with weakened immune systems, such as after surgery. It also reduced LDL cholesterol at a slightly lower dose (125 mg/day) in those with type 2 diabetes in a clinical trial of 48 people after 12 weeks. Importantly, all studies found that Pycnogenol has to be taken at least 5 weeks before the allergy season in order to see potential benefits, with the best results in those who take it 7-8 weeks ahead. However, it can also be used topically. Pycnogenol can help control blood pressure, which helps improve overall heart health. Are there any risks to taking it? According to some researchers, Pycnogenol may lower blood pressure by relaxing blood vessels, reducing free radicals, and lowering inflammation. In the control group, there were five thrombotic events; whereas the Pycnogenol-treated subjects only experienced nonthrombotic, local flare-ups. Pycnogenol French maritime pine bark extract acts as a potent blend of antioxidants, it is a natural anti-inflammatory, stimulates generation of collagen and hyaluronic acid and help with natural dilation of blood vessels by supporting production of nitric oxide. Placebo capsules were given to control subjects at the same times. Align your health hacks with your genes for optimal health & cognitive function. Today's Dietitian: "Pycnogenol Supplement Offers Promise for Managing a Variety of Conditions." Lets begin with asthma. A review was conducted of French maritimepine bark extract, specifically using the nutritional supplement Pycnogenol. Pycnogenol significantly reduced the swelling as well as the feeling of heaviness. Commonly called arthritis, osteoarthritis is caused when the cartilage on your joints begins to wear down. More research is needed to see how this supplement affects all of these conditions. Pine bark extract is composed of 80% to 85% proanthocyanidins, the monomers catechin and taxifolin (5%), and phenolic acids, including derivatives of benzoic and cinnamic acids (2% to 4%). $31.99. If a blood clot blocks the normal blood flow, it is known as thrombosis. Several studies show how Pycnogenol helps block platelet formation and thus helps prevent thrombosis. That way, your doctor can check on any potential side effects or interactions with medications. The flesh of the grape contains approximately 1/20th-1/100th of the total antioxidant capacity of the seed or the skin. which enables users to obtain detailed information and reports based on their genome. Another study found this supplement can even halt progression of vision . Side Effects of Pycnogenol. Pycnogenol effects on skin elasticity and hydration coincide with increased gene expressions of collagen type I and hyaluronic acid synthase in women [Abstract]. Frustrated by the lack of good information and tools, Joe decided to embark on a learning journey to decode his DNA and track his biomarkers in search of better health. Mental function. Next, the doctors discuss the link between salt and hypertension, and Dr. Steve gives his insight on drinking red wine for a healthy heart. Start with a low dose so you can be sure it doesnt cause any side effects. Pycnogenol is a patented formulation of Pine Bark Extract which is standardized to 65-75% Procyanidin compounds by weight. Pycnogenol treatment resulted in more normal-looking sperm. It also reduced the size of scars. What gives pine bark extract its notoriety as a powerful ingredient and super antioxidant is that its loaded with oligomeric proanthocyanidin compounds, OPCs for short. Results failed to show any efficacy of Pycnogenol or methylphenidate when compared to placebo. Eye health. In 1535, a French explorer by the name of Jacques Cartier found himself ice-bound on the St. Lawrence River. Pycnogenol (pic-noj-en-all) is a natural plant extract originating from the bark of the maritime pine that grows along the coast of southwest France and is found to contain a unique combination of procyanidins, bioflavonoids and phenolic acids, which offer extensive natural health benefits. Flavonoids and proanthocyanidins within these fruits can . A study of 58 people with high blood pressure suggests that even lower doses (100 mg/day) may improve blood vessel health and reduce markers of high blood pressure (endothelin-1) after 12 weeks. Studies have also safely used Pycnogenol in children and during pregnancy. (2006). If possible, try to get pine bark extract from a local supplier, such as a health food store.